Abriva 400mg Tablet Uses, Side Effects, Price in Pakistan (2026) with Picture
What is Abriva 400mg Tablet?
Abriva 400mg Tablet is a prescription antiviral medicine that contains Sofosbuvir 400mg as its active ingredient. It is manufactured by CCL Pharmaceuticals and is primarily used for the treatment of chronic Hepatitis C virus (HCV) infection. Unlike antibiotics, Abriva does not treat bacterial infections. Instead, it targets the Hepatitis C virus and helps stop it from multiplying inside the body. Doctors usually prescribe this medicine together with other antiviral medicines because combination therapy provides better treatment results than using Sofosbuvir alone.
The medicine is available in Pakistan only with a valid prescription. Patients should never start or stop taking Abriva without consulting a qualified healthcare provider. Treatment duration usually ranges from 8 to 24 weeks, depending on the patient’s liver condition, virus genotype, and previous treatment history.
Active Ingredient (Sofosbuvir 400mg)
The active ingredient in Abriva is Sofosbuvir, a direct-acting antiviral (DAA). It works by blocking the NS5B RNA polymerase enzyme, which the Hepatitis C virus needs to reproduce. When the virus cannot replicate, its amount in the bloodstream gradually decreases, allowing the liver to recover over time.
Because Hepatitis C can lead to liver cirrhosis, liver failure, or liver cancer if left untreated, medicines like Abriva have significantly improved treatment success rates. Modern antiviral therapies containing Sofosbuvir achieve cure rates exceeding 95% in many eligible patients when taken correctly with companion medicines.
Abriva 400mg Uses
Doctors prescribe Abriva 400mg for:
- Chronic Hepatitis C infection
- Treatment of different Hepatitis C genotypes
- Combination therapy with other antiviral medicines
- Some patients awaiting or recovering from liver transplantation
- Selected patients with liver disease under specialist supervision
Abriva is not effective against Hepatitis B or HIV unless prescribed as part of a specialized treatment plan. Never use this medicine without proper diagnosis through laboratory testing.
How to Take Abriva 400mg
Take one tablet exactly as prescribed by your doctor, usually once daily, with or without food. Swallow the tablet whole with water. Do not crush, split, or chew it.
If you miss a dose and remember within a short time, take it immediately. If it is almost time for the next dose, skip the missed dose. Never take two doses together to make up for a forgotten tablet.
Complete the entire treatment course even if you start feeling better. Stopping treatment early may reduce its effectiveness and increase the chance of treatment failure.
Abriva 400mg Side Effects
Like all medicines, Abriva may cause side effects, although not everyone experiences them.
Common Side Effects
- Headache
- Fatigue
- Nausea
- Diarrhea
- Difficulty sleeping
- Dizziness
- Mild skin rash
- Irritability
These effects are generally mild and improve as treatment continues.
Serious Side Effects
Seek immediate medical attention if you experience:
- Severe allergic reactions
- Difficulty breathing
- Swelling of the face or throat
- Severe skin reactions
- Yellowing of the eyes that worsens
- Severe weakness
- Unusual bleeding or bruising
These reactions are uncommon but require urgent medical evaluation.
Warnings and Precautions
Before taking Abriva, tell your doctor if you have:
- Kidney disease
- Previous Hepatitis B infection
- Liver cirrhosis
- Diabetes
- Pregnancy or plans for pregnancy
- Breastfeeding
Regular blood tests may be required during treatment to monitor liver function and treatment response. Certain medicines such as amiodarone and some anticonvulsants may interact with Sofosbuvir, so always inform your doctor about every medicine or supplement you take.
Abriva 400mg Price in Pakistan (2026)
The price of Abriva 400mg varies depending on the pharmacy and city.
| Pharmacy | Approximate Price |
|---|---|
| Servaid Pharmacy | PKR 2,900 |
| SehatMund | PKR 3,500 |
| SehatMedi | PKR 5,868 |
Prices may change over time due to stock availability, taxes, and supplier updates. Always confirm the latest price before purchasing.
Storage Instructions
Store Abriva tablets:
- Below 30°C
- In a dry place
- Away from sunlight
- Keep out of children’s reach
- Store in the original packaging
Never use expired medicine.
Conclusion
Abriva 400mg Tablet is an important antiviral medicine containing Sofosbuvir 400mg for treating chronic Hepatitis C infection. When taken exactly as prescribed and combined with appropriate antiviral medicines, it offers excellent cure rates for many patients. While common side effects such as headache, fatigue, and nausea are usually manageable, regular medical follow-up is essential throughout treatment. Since this medicine is prescription-only, always consult a qualified healthcare professional before starting therapy.
Frequently Asked Questions (FAQs)
1. What is Abriva 400mg used for?
It is mainly used to treat chronic Hepatitis C virus (HCV) infection.
2. Is Abriva an antibiotic?
No. It is an antiviral medicine, not an antibiotic.
3. Can I buy Abriva without a prescription?
No. It is a prescription-only medicine in Pakistan.
4. What are the common side effects?
Headache, fatigue, nausea, diarrhea, dizziness, and difficulty sleeping are among the most common side effects.
5. How much does Abriva 400mg cost in Pakistan?
Depending on the pharmacy, the current price generally ranges from approximately PKR 2,900 to PKR 5,900.